Looks like headers beginning with "X-" have been removed from CGI output in v10.1.
This is problematic for the Drupal CMS since it is setting its own headers for security. Here is a sample set of response headers that have been removed.
X-Drupal-Ajax-Token: 1
X-Frame-Options: SAMEORIGIN
X-Generator: Drupal 8 (https://www.drupal.org)
X-UA-Compatible: IE=edge
x-content-type-options: nosniff
The main one that is causing problems is X-Drupal-Ajax-Token as it is used for verification of XMLHttpRequest responses to prevent cross-site scripting attacks.
More info:
https://api.drupal.org/api/drupal/includes!ajax.inc/function/ajax_set_verification_header/7https://www.drupal.org/node/2580191